Recombinant human ADRB1 Gly389 + GsaL fusion protein (ab90784)

製品の概要

  • 製品名Recombinant human ADRB1 Gly389 + GsaL fusion protein
  • タンパク質長Full length protein

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号P08588
    • 生物種Human
    • 分子量111 kDa
    • 配列の追加情報Tagged at the N terminus of the ADRB1 with a DDDDK tag. The C terminus of the ADRB1 is linked to the N terminus of the Gs alpha L with a His tag. 90kDa + 36kDa.

特性

Our Abpromise guarantee covers the use of ab90784 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性Activity: 4.5 - 10 pmol/mg
  • アプリケーション

    Functional Studies

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • Adenylate cyclase stimulating G alpha protein
    • ADRB1R
    • Adrenergic beta1 receptor
    • AHO
    • B1AR
    • Beta 1 adrenergic receptor
    • Beta 1 adrenoreceptor
    • BETA1AR
    • C20orf45
    • GNAS
    • GNAS complex locus
    • GNAS1
    • GPSA
    • GSA
    • GSP
    • Guanine nucleotide binding protein (G protein) alpha stimulating activity polypeptide 1
    • Guanine nucleotide binding protein G(s) subunit alpha isoforms short
    • Guanine nucleotide regulatory protein
    • MGC33735
    • PHP1A
    • PHP1B
    • POH
    • RHR
    see all
  • 関連性ADRB1 belongs to a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in ADRB1 have been shown to affect the resting heart rate and can be involved in heart failure. ADRB1 Gly389 is a common polymorphic variant of ADRB1. GsaL is the long splice variant of the alpha-subunit of the heterotrimeric G-protein Gs. Gs activates the effector adenylate cyclase. GsaL differs from the short splice variant by a 15 amino acid insert between the ras-like domain and the alpha-helical domain.
  • 細胞内局在ADRB1: Cell membrane; Multi-pass membrane protein. Note: Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression.

Recombinant human ADRB1 Gly389 + GsaL fusion protein (ab90784) 使用論文

ab90784 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab90784.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"