Recombinant Human Adenylosuccinate Lyase protein (ab113582)

製品の概要

  • 製品名Recombinant Human Adenylosuccinate Lyase protein
  • タンパク質長Full length protein

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P30566
    • 生物種Human
    • 配列MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSMAAGGDHGSPDSYR SPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQE MKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCY VGDNTDLIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQ LTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEG DDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHK ICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTL VMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVV YPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVV KQEGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEE VYPLLKPYESVMKVKAELCL
    • 分子量59 kDa including tags
    • 領域1 to 484
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab113582 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.
    ab113582 is purified using conventional chromatography techniques: anion exchange chromatography followed by gel filtration chromatography with 20mM Tris pH 7.5, 2mM EDTA. No detergents such as urea, Triton or Tween etc. were used to purify the proteins.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT, 40% Glycerol, 0.58% Sodium chloride

関連情報

  • 別名
    • Adenylosuccinase
    • Adenylosuccinate lyase
    • ADSL
    • AMPS
    • ASase
    • ASL
    • OTTHUMP00000199172
    • OTTHUMP00000199173
    • PUR8_HUMAN
    see all
  • 組織特異性Ubiquitously expressed. Both isoforms are produced by all tissues. Isoform 2 is 10-fold less abundant than isoform 1.
  • パスウェイPurine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.
    Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.
  • 関連疾患Defects in ADSL are the cause of adenylosuccinase deficiency (ADSL deficiency) [MIM:103050]. ADSL deficiency is an autosomal recessive disorder characterized by the accumulation in the body fluids of succinylaminoimidazole-carboxamide riboside (SAICA-riboside) and succinyladenosine (S-Ado). Most children display marked psychomotor delay, often accompanied by epilepsy or autistic features, or both, although some patients may be less profoundly retarded. Occasionally, growth retardation and muscular wasting are also present.
  • 配列類似性Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  • Information by UniProt

Recombinant Human Adenylosuccinate Lyase protein 画像

  • 15% SDS-PAGE showing ab113582 at approximately 59kDa (3µg).

Recombinant Human Adenylosuccinate Lyase protein (ab113582) 使用論文

ab113582 has not yet been referenced specifically in any publications.

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