製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 分子量
      22 kDa
    • 領域
      892 to 1089
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab125984 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態
    Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • 再構成
    Reconstitute with water to desired concentration.

関連情報

  • 別名
    • 136 kDa double-stranded RNA-binding protein
    • 136kDa double stranded RNA binding protein
    • ADAR
    • Adar 1
    • Adar1
    • Adenosine deaminase acting on RNA 1 A
    • Adenosine deaminase RNA specific
    • Adenosine deaminase RNA specific 1
    • Adenosine deaminase that act on RNA
    • AGS6
    • AV242451
    • Double stranded RNA specific adenosine deaminase
    • Double-stranded RNA-specific adenosine deaminase
    • Double-stranded RNA-specific editase Adar
    • DRADA
    • Dsh
    • Dsrad
    • DSRAD_HUMAN
    • dsRNA adenosine deaminase
    • EC 3.5.4.-
    • G1P1
    • IFI 4
    • IFI-4
    • IFI4
    • Ifi4 protein
    • Interferon induced protein 4
    • Interferon inducible protein 4
    • Interferon-inducible protein 4
    • K88DSRBP
    • mZaADAR
    • P136
    • Pre-mRNA adenosine deaminase
    • RNA adenosine deaminase 1
    • RNA-editing deaminase 1
    • RNA-editing enzyme 1
    see all
  • 機能
    Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site-selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression.
  • 組織特異性
    Ubiquitously expressed, highest levels were found in brain and lung.
  • 関連疾患
    Defects in ADAR are a cause of dyschromatosis symmetrical hereditaria (DSH) [MIM:127400]; also known as reticulate acropigmentation of Dohi. DSH is a pigmentary genodermatosis of autosomal dominant inheritance characterized by a mixture of hyperpigmented and hypopigmented macules distributed on the dorsal parts of the hands and feet.
  • 配列類似性
    Contains 1 A to I editase domain.
    Contains 2 DRADA repeats.
    Contains 3 DRBM (double-stranded RNA-binding) domains.
  • 翻訳後修飾
    Sumoylation reduces RNA-editing activity.
  • 細胞内局在
    Cytoplasm. Nucleus > nucleolus. Isoform 1 is found predominantly in cytoplasm but appears to shuttle between the cytoplasm and nucleus. Isoform 5 is found exclusively in the nucleolus.
  • Information by UniProt

参考文献

ab125984 has not yet been referenced specifically in any publications.

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