製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • 生物種
      Human
    • 領域
      214 to 672

特性

Our Abpromise guarantee covers the use of ab83118 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 1x Laemmli Buffer (2.5% Glycerol, 1% SDS, 0.1% Bromophenol blue, 50mM DTT, 25mM Tris HCl, pH 6.8)

関連情報

  • 別名
    • A disintegrin and metalloprotease domain 10
    • A disintegrin and metalloproteinase domain 10
    • AD 10
    • AD10
    • AD18
    • ADA10_HUMAN
    • ADAM 10
    • ADAM metallopeptidase domain 10
    • ADAM10
    • CD 156c
    • CD156c
    • CD156c antigen
    • CDw156
    • disintegrin and metalloproteinase domain containing protein 10
    • Disintegrin and metalloproteinase domain-containing protein 10
    • HsT 18717
    • HsT18717
    • Kuz
    • Kuzbanian
    • Kuzbanian protein homolog
    • Kuzbanian, Drosophila, homolog of
    • MADM
    • Mammalian disintegrin metalloprotease
    • Mammalian disintegrin-metalloprotease
    • RAK
    see all
  • 機能
    Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-
    -Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis.
  • 組織特異性
    Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.
  • 配列類似性
    Contains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
  • ドメイン
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻訳後修飾
    The precursor is cleaved by a furin endopeptidase.
  • 細胞内局在
    Cell membrane. Endomembrane system. Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi.
  • Information by UniProt

参考文献

ab83118 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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