Recombinant human Activin A Receptor Type IB protein (ab55682)

製品の概要

法規制情報

製品の詳細

  • 由来
    Recombinant
  • 由来
    Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 分子量
      57 kDa
    • 領域
      150 to 505
    • タグ
      GST tag N-Terminus
    • 配列の追加情報
      Recombinant fragment corresponding to amino acids 150-end of Human Activin A Receptor Type IB.

関連製品

特性

Our Abpromise guarantee covers the use of ab55682 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Functional Studies

    SDS-PAGE

  • 精製度
    > 95 % SDS-PAGE.
    ab55682 purity was determined by densitometry.
  • 製品の状態
    Liquid
  • 備考

    ab91090 (Cow Casein full length protein) can be utilized as a substrate for assessing Kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • Activin A receptor type 1B
    • Activin A receptor type II like kinase 4
    • Activin A type 1B receptor
    • Activin A type IB receptor
    • Activin receptor like kinase 4
    • Activin receptor type 1B
    • Activin receptor type IB
    • Activin receptor type-1B
    • Activin receptor-like kinase 4
    • ACTR IB
    • ACTR-IB
    • ACTRIB
    • ACV1B_HUMAN
    • ACVR 1B
    • Acvr1b
    • ACVRLK 4
    • ACVRLK4
    • ALK 4
    • ALK-4
    • ALK4
    • Serine(threonine) protein kinase receptor R2
    • Serine/threonine-protein kinase receptor R2
    • SKR 2
    • SKR2
    see all
  • 機能
    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TDP2.
  • 組織特異性
    Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.
  • 配列類似性
    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • 翻訳後修飾
    Autophosphorylated.
  • 細胞内局在
    Membrane.
  • Information by UniProt

画像

  • Sample Kinase Activity assay plot, using ab55682.
  • Sample purity data showing SDS-PAGE analysis of ab55682, with molecular weight markers.

参考文献

ab55682 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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