製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      ILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDA KELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANA ANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDE ATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKI KEQG
    • 領域
      587 to 790

特性

Our Abpromise guarantee covers the use of ab125989 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態
    Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride, 28.8% Guanidine HCl

  • 再構成
    Reconstitute with water to desired concentration.

関連情報

  • 別名
    • ABCB 5
    • ABCB5
    • ABCB5 P-gp
    • ABCB5_HUMAN
    • ABCB5alpha
    • ABCB5beta
    • ATP binding cassette protein
    • ATP binding cassette sub family B (MDR/TAP) member 5
    • ATP binding cassette sub family B member 5
    • ATP-binding cassette sub-family B member 5
    • EST422562
    • P glycoprotein ABCB5
    • P-glycoprotein ABCB5
    see all
  • 機能
    Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas.
  • 組織特異性
    Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues.
  • 配列類似性
    Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
    Contains 1 ABC transmembrane type-1 domain.
    Contains 2 ABC transporter domains.
  • 細胞内局在
    Cell membrane.
  • Information by UniProt

参考文献

ab125989 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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