製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      NCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNR FGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQYQLPSSL SSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLS LHKNQTVVDVA
    • 領域
      2085 to 2245

特性

Our Abpromise guarantee covers the use of ab125995 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態
    Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride, 0.2% Guanidine HCl

  • 再構成
    Reconstitute with water to desired concentration.

関連情報

  • 別名
    • ABC 1
    • ABC Transporter 1
    • ABC-1
    • ABC1
    • ABCA 1
    • ABCA1
    • ABCA1_HUMAN
    • ATP binding Cassette 1
    • ATP binding cassette sub family A ABC1 member 1
    • ATP binding cassette sub family A member 1
    • ATP binding Cassette Transporter 1
    • ATP-binding cassette 1
    • ATP-binding cassette sub-family A member 1
    • ATP-binding cassette transporter 1
    • CERP
    • Cholesterol efflux regulatory protein
    • FLJ14958
    • HDLDT1
    • Membrane bound
    • MGC164864
    • MGC165011
    • TD
    • TGD
    see all
  • 機能
    cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.
  • 組織特異性
    Widely expressed, but most abundant in macrophages.
  • 関連疾患
    Defects in ABCA1 are a cause of high density lipoprotein deficiency type 1 (HDLD1) [MIM:205400]; also known as analphalipoproteinemia or Tangier disease (TGD). HDLD1 is a recessive disorder characterized by absence of high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness.
    Defects in ABCA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) [MIM:604091]; also known as familial hypoalphalipoproteinemia (FHA). HDLD2 is inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux.
  • 配列類似性
    Belongs to the ABC transporter superfamily. ABCA family.
    Contains 2 ABC transporter domains.
  • ドメイン
    Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
  • 翻訳後修飾
    Phosphorylation on Ser-2054 regulates phospholipid efflux.
    Palmitoylation by DHHC8 is essential for membrane localization.
  • 細胞内局在
    Membrane.
  • Information by UniProt

参考文献

ab125995 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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