Recombinant Human 67kDa Laminin Receptor protein (ab114294)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIIN LKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIA GRFTPGTFTNQIQAAFREPRLLVVTDPRAGHQPLTEASYVNLPTIALCNT DSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPD LYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTATQPEVADWSE GVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS
    • 分子量
      59 kDa including tags
    • 領域
      1 to 295

特性

Our Abpromise guarantee covers the use of ab114294 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    ELISA

    SDS-PAGE

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • 34/67 kDa laminin receptor
    • 37 kDa laminin receptor precursor
    • 37/67 kDa laminin receptor
    • 37LRP
    • 40S ribosomal protein SA
    • 67 kDa laminin receptor
    • 67LR
    • Colon carcinoma laminin binding protein
    • Colon carcinoma laminin-binding protein
    • LAMBR
    • Laminin receptor 1
    • Laminin-binding protein precursor p40
    • LamR
    • LAMR 1
    • LAMR1
    • LBP
    • LBP/p40
    • LRP
    • LRP/LR
    • Multidrug resistance associated protein MGr1 Ag
    • Multidrug resistance associated protein MGr1Ag
    • Multidrug resistance-associated protein MGr1-Ag
    • NEM/1CHD4
    • p40
    • Ribosomal Protein SA
    • rpsA
    • RSSA_HUMAN
    • SA
    see all
  • 機能
    Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.
  • 配列類似性
    Belongs to the ribosomal protein S2P family.
  • 翻訳後修飾
    Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
    Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
  • 細胞内局在
    Cell membrane. Cytoplasm. Nucleus. 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Co-localizes with PPP1R16B in the cell membrane.
  • Information by UniProt

画像

  • 12.5% SDS-PAGE image showing ab114294 at approx 58.56kDa. Stained with Coomassie Blue.

参考文献

ab114294 has not yet been referenced specifically in any publications.

レビューと Q&A

Unfortunately, we haven’t tested if ab114294 is active nor the receptor conformation to bind a protein that the laminin receptor recognises on the cell surface.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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