Recombinant Hepatitis C Virus genotype 2a NS5 protein (ab68374)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 領域2212 to 2313
    • タグGST tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab68374 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性This protein is immunoreactive with sera of HCV-infected individuals.
  • アプリケーション

    Western blot

    ELISA

  • 精製度> 95 % SDS-PAGE.
    This protein was purified by proprietary chromatographic techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 0.2% Triton-X, 1.5M Urea, 25mM Tris HCl, pH 8

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • HCV NS5
    • Hepatitis virus NS5A
    • Non structural protein 5A
    • NS5A
    • p56
    see all
  • 関連性HCV is classified into the genus Hepacivirus of the family Flaviviridae. Like all the members of the family, HCV is an enveloped, single-stranded, positive-sense RNA virus. Its genome (about 9600 nt) is flanked at both termini by conserved, highly structured non-translated regions (NTRs) and encodes a polyprotein precursor (about 3000 aa), which is proteolytically processed by host and viral proteases to produce the structural (core, E1, E2 and p7) and non-structural (NS2, NS3, NS4A, NS4B, NS5A and NS5B) proteins of the virus. Recently, an additional protein has been identified, whose function remains unknown. HCV is a major cause of acute hepatitis and chronic liver disease, including cirrhosis and liver cancer. Currently, no vaccine is currently available to prevent hepatitis C, and therapeutic approaches to treatment are still limited. NS5A is a ~56 kDa pleiotropic protein with key roles in both viral RNA replication and modulation of the physiology of the host cell. It's exact role is not currently known (2008). NS5B RNA-dependant RNA polymerase is responsible for replication of the hepatitis C viral genome, and is currently a principal target for chemotherapeutic inhibition of HCV replication.

Recombinant Hepatitis C Virus genotype 2a NS5 protein (ab68374) 使用論文

ab68374 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"