Recombinant Hepatitis C Virus Core Antigen protein (ab49017)



  • 由来
  • 由来
    Escherichia coli
  • アミノ酸配列
    • 領域
      2 to 192
    • 配列の追加情報
      β-galactosidase (114 kDa) fused at the N-terminus


Our Abpromise guarantee covers the use of ab49017 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    Reacts strongly with human HCV positive serum.
  • アプリケーション



    Western blot

  • 精製度
    > 95 % SDS-PAGE.

  • 製品の状態
  • 備考

    Genotype 1B. Reacts strongly with human HCV positive serum.

  • Concentration information loading...


  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 8M Urea, 20mM Tris HCl, 10mM Beta mercaptoethanol, pH 8


  • 別名
    • Core protein p21
    • HCV core antigen
    • HCV core protein
    • Hepatitis C Virus core protein
  • 関連性
    The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
  • 細胞内局在
    Endoplasmic reticulum


ab49017 has not yet been referenced specifically in any publications.

レビューと Q&A

Q1. If we do electrophoresis, Is it in the 22 Kda location?
A1: This protein is the 22kDa HCV antigen fused to the 114kDa beta galactosidase protein. So total molecular weight of this fusition protein is 136kDa.

Q2. what is the...

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Thank you very much for contacting us with your question.

The antigen ab49017 is suitable to use in an ELISA. We do not have any free samples, but we do fully guarantee this product to work as specified on the datasheet, and we will offer a r...

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Thank you for your reply.

I am very sorry but I am not able to send a full vial of this protein for free, theywill only be available at the list price.

I apologize that I can not be more helpful in this case. Please let me know if y...

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Thank you so much for contacting us with your question.

We only have full size vials of all of our products, so unfortunately we do not have a small sample to send. We do fully guarantee the protein to work as specified on the datasheet (in E...

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