Recombinant Hepatitis B Virus Core Antigen protein (ab49014)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • 領域
      1 to 144
    • 配列の追加情報
      Deleted DNA binding domain. Fully competent for self-assembly.

特性

Our Abpromise guarantee covers the use of ab49014 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    Reacts strongly with human HBV positive serum.
  • アプリケーション

    Western blot

    ELISA

  • 精製度
    > 95 % SDS-PAGE.

  • 製品の状態
    Liquid
  • 備考


    During infection, the C gene of HBV often displays genetic deletions within the tip of the protruding spikes of HBcAg, which are known to contain the major site for antibody binding . These have been referred to as core internal deletion variants, and they often appear in end stage liver disease. Depending on the nature of the deletion, they may still form functional capsids,

    Reacts strongly with human HBV positive serum.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 75mM Sodium chloride, 7.5mM PBS, pH 7.2

関連情報

  • 別名
    • C
    • Capsid protein
    • core
    • Core and e antigen
    • Core antigen
    • Core protein
    • HBc
    • HBcAg
    • HBVgp4
    • Hepatitis B core antigen
    • Hepatitis B Virus core antigen
    • p21.5
    • precore/core protein
    see all
  • 関連性
    Hepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner "core particle" enclosing the viral genome. The icosahedral core particle contains 180 or 240 copies of the core protein. HBcAg is one of the three major clinical antigens of hepatitis B virus but disappears early in the course of infection. The hepatitis B virus core antigen (HBcAg) is a highly immunogenic subviral particle and functions as both a T-cell-dependent and a T-cell-independent antigen. Therefore, HBcAg may be a promising candidate target for therapeutic vaccine control of chronic HBV infection.
  • 細胞内局在
    Capsid protein: Virion. Host cytoplasm, hepatocyte nucleus.

参考文献

ab49014 has not yet been referenced specifically in any publications.

レビューと Q&A

All three of the core antigen proteins you asked about are from the HBV320 strain, genotype D. The article at this URL, https://www.ncbi.nlm.nih.gov/pubmed/?term=8336122, identifies the genotype of HBV320 and many other strains in Figures 1 and 2.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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