This product is an active protein and may elicit a biological response in vivo, handle with caution.
Cyclophilin like protein
peptidyl prolyl cis trans isomerase B
Peptidyl prolyl cis trans isomerase B precursor
Peptidyl-prolyl cis-trans isomerase B
Peptidylprolyl isomerase B
peptidylprolyl isomerase B (cyclophilin B)
機能PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
関連疾患Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9) [MIM:259440]. OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients.
配列類似性Belongs to the cyclophilin-type PPIase family. PPIase B subfamily. Contains 1 PPIase cyclophilin-type domain.
細胞内局在Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.