製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Cow

特性

Our Abpromise guarantee covers the use of ab91596 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性ATPase Activity Assay: Positive
  • アプリケーション

    SDS-PAGE

    Western blot

    Functional Studies

  • 製品の状態Liquid
  • 備考Endotoxin Concentration: < 50 EU/mg as determined by Limulus Amebocyte Lysate (LAL) gel clot assay
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 300mM Sodium chloride, 30mM Tris, 2mM DTT, 1mM EDTA, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • 2410008N15Rik
    • Constitutive heat shock protein 70
    • Epididymis luminal protein 33
    • Epididymis secretory sperm binding protein Li 72p
    • Heat shock 70 kDa protein 8
    • Heat shock 70kD protein 10
    • Heat shock 70kD protein 8
    • Heat shock 70kDa protein 8
    • Heat shock cognate 71 kDa protein
    • Heat shock cognate protein 54
    • Heat shock cognate protein 71 kDa
    • Heat shock protein 8
    • Heat shock protein A8
    • Heat-shock70-KD protein 10, formerly
    • HEL 33
    • HEL S 72p
    • HSC54
    • HSC71
    • Hsc73
    • HSP71
    • HSP73
    • HSP7C_HUMAN
    • HSPA10
    • HSPA8
    • LAP1
    • Lipopolysaccharide associated protein 1
    • LPS associated protein
    • LPS associated protein 1
    • MGC102007
    • MGC106514
    • MGC114311
    • MGC118485
    • MGC131511
    • MGC29929
    • N-myristoyltransferase inhibitor protein 71
    • NIP71
    see all
  • 機能Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.
  • 組織特異性Ubiquitous.
  • 配列類似性Belongs to the heat shock protein 70 family.
  • ドメインThe N-terminal 1-386 residues constitute the ATPase domain, while residues 387-646 form the peptide-binding domain.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
    ISGylated.
  • 細胞内局在Cytoplasm. Melanosome. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt

Recombinant cow Hsc70 protein (ab91596) 使用論文

ab91596 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"