The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
エンドトキシン・レベル< 0.100 Eu/µg
The biological activity of this product was determined by its ability to chemoattract human activated T cells cultured in the presence of IL-2 using a concentration range of 10.0-100.0 ng/ml.
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Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
C-C motif chemokine 21
Chemokine CC motif ligand 21
Secondary lymphoid-tissue chemokine
Small inducible cytokine A21
Small-inducible cytokine A21
機能Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.
組織特異性Highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in tonsil, fetal heart and fetal spleen.
配列類似性Belongs to the intercrine beta (chemokine CC) family.