機能Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.
配列類似性Belongs to the prohibitin family.
発生段階Levels of expression in fibroblasts decrease heterogeneously during cellular aging.
細胞内局在Mitochondrion inner membrane. Cytoplasm. Nucleus. Also cytoplasmic and nuclear.