製品の概要

  • 製品名
    Anti-RDH12 antibody
  • 製品の詳細
    Rabbit polyclonal to RDH12
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 180-229 (IGKIPFHDLQ SEKRYSRGFA YCHSKLANVL FTRELAKRLQ GTGVTTYAVH) of Human RDH12 (NP_689656).

  • ポジティブ・コントロール
    • Transfected 293T cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab87038 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 35 kDa (predicted molecular weight: 35 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能
    Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments.
  • 組織特異性
    Widely expressed, mostly in eye, kidney, brain, skeletal msucle and stomach.
  • 関連疾患
    Defects in RDH12 are the cause of Leber congenital amaurosis type 13 (LCA13) [MIM:612712]. LCA designates a clinically and genetically heterogeneous group of childhood retinal degenerations, generally inherited in an autosomal recessive manner. Affected infants have little or no retinal photoreceptor function as tested by electroretinography. LCA represents the most common genetic cause of congenital visual impairment in infants and children.
    Defects in RDH12 are the cause of retinitis pigmentosa type 53 (RP53) [MIM:612712]. RP53 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • 配列類似性
    Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Information by UniProt
  • 参照データベース
  • 別名
    • All trans and 9 cis retinol dehydrogenase antibody
    • All-trans and 9-cis retinol dehydrogenase antibody
    • LCA 3 antibody
    • LCA13 antibody
    • LCA3 antibody
    • RDH 12 antibody
    • RDH12 antibody
    • RDH12_HUMAN antibody
    • Retinol dehydrogenase 12 (all trans/9 cis/11 cis) antibody
    • Retinol dehydrogenase 12 all trans and 9 cis antibody
    • Retinol dehydrogenase 12 antibody
    • RP53 antibody
    • SDR7C2 antibody
    • Short chain dehydrogenase/reductase family 7C member 2 antibody
    see all

Anti-RDH12 antibody 画像

  • Anti-RDH12 antibody (ab87038) at 1 µg/ml (in 5% skim milk / PBS buffer) + Transfected 293T cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 35 kDa
    Observed band size : 35 kDa

プロトコール

Anti-RDH12 antibody (ab87038) 使用論文

This product has been referenced in:
  • Ozaki R  et al. Reprogramming of the retinoic acid pathway in decidualizing human endometrial stromal cells. PLoS One 12:e0173035 (2017). WB . Read more (PubMed: 28253328) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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