Anti-RCC1 抗体 - Aminoterminal end, prediluted (ab53650)

製品の概要

  • 製品名Anti-RCC1 antibody - Aminoterminal end, prediluted
    RCC1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to RCC1 - Aminoterminal end, prediluted
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide corresponding to N terminal of human RCC1

  • ポジティブ・コントロール
    • Human colon carcinoma, A431 and Jurkat cells

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab53650 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: Ready-to-use for 30 min at RT. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.
    • 配列類似性Contains 7 RCC1 repeats.
    • 翻訳後修飾N-terminal methylation by METTL11A/NTM1 is required for binding double-stranded DNA and stable chromatin association. Di-and trimethylation produce a permanent positive charge on the amino group, which facilitate electrostatic binding to the phosphate groups on DNA, while inhibiting histone-binding. Methylated tail helps retain RCC1 on chromosomes during nucleotide exchange on Ran.
    • 細胞内局在Nucleus. Cytoplasm. Becomes dispersed throughout the cytoplasm during mitosis.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Cell cycle regulatory protein antibody
      • CHC 1 antibody
      • CHC1 antibody
      • Chromosome condensation 1 antibody
      • Chromosome condensation protein 1 antibody
      • Guanine nucleotide releasing protein antibody
      • HERC2 antibody
      • Ran GEF antibody
      • RanGEF antibody
      • RCC 1 antibody
      • RCC1 antibody
      • RCC1 I antibody
      • RCC1_HUMAN antibody
      • Regulator of chromosome condensation 1 antibody
      • Regulator of chromosome condensation antibody
      • SHEP1 antibody
      • SNHG3 RCC1 antibody
      • SNHG3 RCC1 readthrough transcript antibody
      see all

    Anti-RCC1 antibody - Aminoterminal end, prediluted 画像

    • ab53650, used neat, staining Human RCC1 in Colon carcinoma, using Immunohistochemistry, Formalin fixed Paraffin embedded tissue

    Anti-RCC1 antibody - Aminoterminal end, prediluted (ab53650) 使用論文

    ab53650 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"