製品の概要

  • 製品名Anti-RCC1 antibody
    RCC1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to RCC1
  • アプリケーション適用あり: IHC-P, IP, ICC/IF, WBmore details
  • 種交差性
    交差種: Human, Xenopus laevis
  • 免疫原

    Recombinant full length protein (Xenopus laevis) - His-tagged and purified from E. coli.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab4785 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use at an assay dependent concentration.
IP Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration.
WB 1/500. Detects a band of approximately 64 kDa (predicted molecular weight: 45 kDa).

ターゲット情報

  • 機能Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.
  • 配列類似性Contains 7 RCC1 repeats.
  • 翻訳後修飾N-terminal methylation by METTL11A/NTM1 is required for binding double-stranded DNA and stable chromatin association. Di-and trimethylation produce a permanent positive charge on the amino group, which facilitate electrostatic binding to the phosphate groups on DNA, while inhibiting histone-binding. Methylated tail helps retain RCC1 on chromosomes during nucleotide exchange on Ran.
  • 細胞内局在Nucleus. Cytoplasm. Becomes dispersed throughout the cytoplasm during mitosis.
  • Information by UniProt
  • 参照データベース
    • 別名
      • Cell cycle regulatory protein antibody
      • CHC 1 antibody
      • CHC1 antibody
      • Chromosome condensation 1 antibody
      • Chromosome condensation protein 1 antibody
      • Guanine nucleotide releasing protein antibody
      • HERC2 antibody
      • Ran GEF antibody
      • RanGEF antibody
      • RCC 1 antibody
      • RCC1 antibody
      • RCC1 I antibody
      • RCC1_HUMAN antibody
      • Regulator of chromosome condensation 1 antibody
      • Regulator of chromosome condensation antibody
      • SHEP1 antibody
      • SNHG3 RCC1 antibody
      • SNHG3 RCC1 readthrough transcript antibody
      see all

    Anti-RCC1 antibody 画像

    • ab4785 (1/100) staining RCC1 in Skin tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).



    • Predicted band size : 45 kDa
      ab4785 at a 1/500 dilution staining approximately 64kDa RCC 1 in Xenopus egg extract (lane X, 50µg per lane) and HeLa total cell extract (lane Hu, 50µg per lane) by western blot (ECL, 15 seconds exposure). ab4785 at a 1/500 dilution staining approximately 64kDa RCC 1 in Xenopus egg extract (lane X, 50µg per lane) and HeLa total cell extract (lane Hu, 50µg per lane) by western blot (ECL, 15 seconds exposure).

    Anti-RCC1 antibody (ab4785) 使用論文

    ab4785 has not yet been referenced specifically in any publications.

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    The supplying lab let me know that, unfortunately,they do not have an IP protocol asthe researchers inthe originating lab who tested the antibody in IP haveleft that lab and the records have not been kept. I am v...

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