製品の概要

  • 製品名Anti-RbAp48 antibody
    RbAp48 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to RbAp48
  • アプリケーション適用あり: ICC/IF, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Chicken, Cow, Xenopus laevis, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to Human RbAp48 aa 1-14.
    Sequence:

    MADKFAAFDDAVEEC


    (Peptide available as ab5014)

  • ポジティブ・コントロール
    • WB: HeLa cell lysate.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab3536 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use at an assay dependent concentration.
WB Use a concentration of 0.5 µg/ml. Detects a band of approximately 48 kDa (predicted molecular weight: 47.5 kDa).Can be blocked with RbAp48 peptide (ab5014).

A larger ~60 kDa unknown protein from HeLa cell lysate is also detected.

ターゲット情報

  • 機能Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
  • 配列類似性Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
    Contains 6 WD repeats.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CAF I p48 antibody
    • CAF-1 subunit C antibody
    • CAF-I 48 kDa subunit antibody
    • CAF-I p48 antibody
    • Chromatin assembly factor 1 subunit C antibody
    • Chromatin assembly factor I p48 subunit antibody
    • Chromatin assembly factor/CAF 1 p48 subunit antibody
    • Histone-binding protein RBBP4 antibody
    • MSI1 protein homolog antibody
    • Nucleosome-remodeling factor subunit RBAP48 antibody
    • NURF55 antibody
    • RbAp 48 antibody
    • RBAP48 antibody
    • RBBP-4 antibody
    • RBBP4 antibody
    • RBBP4_HUMAN antibody
    • Retinoblastoma binding protein 4 antibody
    • Retinoblastoma binding protein p48 antibody
    • Retinoblastoma-binding protein 4 antibody
    • Retinoblastoma-binding protein p48 antibody
    see all

Anti-RbAp48 antibody 画像

  • ab3536 staining RbAp48 in Human HeLa cells by immunocytochemistry/ Immunofluorescence.



  • Predicted band size : 47.5 kDa

    Western blot of RpAp48 on 1) Du-148 2) LNCaP and 3) Hep-G2 cell extracts using ab3536.

Anti-RbAp48 antibody (ab3536) 使用論文

This product has been referenced in:
  • Sridharan R & Smale ST Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes. J Biol Chem 282:30227-38 (2007). WB ; Human . Read more (PubMed: 17681952) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"