製品の概要

  • 製品名Anti-RASA1 antibody
    RASA1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to RASA1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to Mouse RASA1 aa 728-777 (C terminal).
    Sequence:

    SNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRT


    Database link: Q91YX7

  • ポジティブ・コントロール
    • Mouse brain lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーConstituents: 98% PBS, 2% Sucrose
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab113969 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 94 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21.
  • 組織特異性In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level).
  • 関連疾患Note=Mutations in the SH2 domain of RASA seem to be oncogenic and cause basal cell carcinomas.
    Defects in RASA1 are the cause of capillary malformation-arteriovenous malformation (CMAVM) [MIM:608354]. CMAVM is a disorder characterized by atypical capillary malformations that are multiple, small, round to oval in shape and pinkish red in color. These capillary malformations are associated with either arteriovenous malformation, arteriovenous fistula, or Parkes Weber syndrome.
    Defects in RASA1 are a cause of Parkes Weber syndrome (PKWS) [MIM:608355]. PKWS is a disorder characterized by a cutaneous flush with underlying multiple micro-arteriovenous fistulas, in association with soft tissue and skeletal hypertrophy of the affected limb.
  • 配列類似性Contains 1 C2 domain.
    Contains 1 PH domain.
    Contains 1 Ras-GAP domain.
    Contains 2 SH2 domains.
    Contains 1 SH3 domain.
  • 翻訳後修飾The N-terminus is blocked.
  • 細胞内局在Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CM AVM antibody
    • CMAVM antibody
    • DKFZp434N071 antibody
    • GAP antibody
    • GTPase activating protein antibody
    • GTPase-activating protein antibody
    • OTTHUMP00000222390 antibody
    • OTTHUMP00000222391 antibody
    • OTTHUMP00000222392 antibody
    • OTTHUMP00000222393 antibody
    • p120GAP antibody
    • p120RASGAP antibody
    • PKWS antibody
    • Ras GTPase-activating protein 1 antibody
    • RAS p21 protein activator (GTPase activating protein) 1 antibody
    • Ras p21 protein activator antibody
    • RASA antibody
    • RASA1 antibody
    • RASA1_HUMAN antibody
    • RasGAP antibody
    • Triphosphatase activating protein antibody
    see all

Anti-RASA1 antibody 画像

  • Anti-RASA1 antibody (ab113969) at 1 µg/ml + Mouse brain lysate at 10 µg

    Predicted band size : 94 kDa
    Gel concentration: 6-18%.

Anti-RASA1 antibody (ab113969) 使用論文

ab113969 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"