製品の概要

  • 製品名Anti-Raptor antibody
    Raptor 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Raptor
  • アプリケーション適用あり: IPmore details
    適用なし: WB
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Guinea pig, Cow, Pig, Chimpanzee, Rhesus monkey, Opossum, Elephant
  • 免疫原

    A region between residues 1 and 50 of human Raptor

  • ポジティブ・コントロール
    • Whole cell lysate from HeLa cells.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab70212 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP
  • 追加情報IP: Use at 2 - 5 µg/mg of lysate.


    Is unsuitable for WB.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation.
    • 組織特異性Highly expressed in skeletal muscle, and in a lesser extent in brain, lung, small intestine, kidney and placenta.
    • 配列類似性Belongs to the WD repeat RAPTOR family.
      Contains 7 WD repeats.
    • 細胞内局在Cytoplasm. Lysosome. Targeting to lysosomes depends on amino acid availability.
    • Information by UniProt
    • 参照データベース
    • 別名
      • KIAA1303 antibody
      • KOG1 antibody
      • Mip1 antibody
      • P150 target of rapamycin (TOR) scaffold protein antibody
      • p150 target of rapamycin (TOR) scaffold protein containing WD repeats antibody
      • P150 target of rapamycin (TOR)-scaffold protein antibody
      • Raptor antibody
      • Regulatory associated protein of mTOR antibody
      • Regulatory associated protein of MTOR complex 1 antibody
      • Regulatory-associated protein of mTOR antibody
      • RPTOR antibody
      • RPTOR_HUMAN antibody
      see all

    Anti-Raptor antibody (ab70212) 使用論文

    ab70212 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab70212.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"