Anti-RAP1 抗体 (ab87319)

製品の概要

• 製品名
  Anti-RAP1 antibody
  RAP1 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to RAP1
• アプリケーション
  適用あり: IHC-Pmore details
• 種交差性
  交差種: Human
  
• 免疫原

  Recombinant full length Human RAP1 (NP_061848.2)

• ポジティブ･コントロール
  • Human Anaplastic Thyroid Carcinoma and Breast Carcinoma

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファー
  Preservative: 0.09% Sodium Azide
  Constituents: 0.1% BSA, Tris buffered saline
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• 特記事項（精製）
  ab87319 was affinity purified using RAP1 immobilized on solid support.
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Epigenetics and Nuclear Signaling
  • Chromosome Structure
  • Telomeres

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 機能
  Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.
• 組織特異性
  Ubiquitous. Highly expressed.
• 配列類似性
  Belongs to the RAP1 family.
  Contains 1 BRCT domain.
  Contains 1 Myb-like domain.
• 翻訳後修飾
  Phosphorylated upon DNA damage, probably by ATM or ATR.
• 細胞内局在
  Nucleus. Cytoplasm. Chromosome. Chromosome > telomere. Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex.

• Target information above from: UniProt accession Q9NYB0 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 54386 Human
  • Omim: 605061 Human
  • SwissProt: Q9NYB0 Human
  • Unigene: 301419 Human
• 別名
  • Dopamine receptor interacting protein 5 antibody
  • Dopamine receptor-interacting protein 5 antibody
  • DRIP 5 antibody

  • DRIP5 antibody
  • hRap1 antibody
  • MGC105533 antibody
  • RAP 1 antibody
  • RAP1 homolog antibody
  • RAP1, yeast, homolog if antibody
  • RAP1, yeast, homolog of antibody
  • Repressor/activator protein 1 homolog antibody
  • TE2IP_HUMAN antibody
  • Telomeric Repeat Binding Factor 2 Interacting Protein antibody
  • Telomeric repeat-binding factor 2-interacting protein 1 antibody
  • TERF2-interacting protein antibody
  • TERF2-interacting telomeric protein 1 antibody
  • TERF2IP antibody
  • TRF2 Interacting Telomeric Protein RAP1 antibody
  • TRF2 interacting telomeric RAP1 protein antibody
  • TRF2-interacting telomeric protein 1 antibody
  • TRF2-interacting telomeric protein antibody

  see all

プロトコール

• Immunohistochemistry protocols