Anti-RANTES 抗体 (Biotin) (ab83135)

製品の概要

  • 製品名
    Anti-RANTES antibody (Biotin)
    RANTES 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to RANTES (Biotin)
  • 由来種
    Rabbit
  • 標識
    Biotin
  • アプリケーション
    適用あり: Sandwich ELISA, WBmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Highly pure (>98%) recombinant mouse RANTES

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab83135 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Sandwich ELISA
WB
  • 追加情報
    ELISA: Use at a concentration of 0.25 - 1 µg/ml. Allows the detection of at least 0.2 - 0.4 ng/well of recombinant murine RANTES.
    sELISA: Use at a concentration of 0.25 - 1 µg/ml. Allows the detection of at least 0.2 - 0.4 ng/well of recombinant murine RANTES.
    Can be paired for ELISA with Rabbit polyclonal to RANTES (ab9915)
    WB: Use at a concentration of 0.1 - 0.2 µg/ml. The detection limit for recombinant murine RANTES is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions. Predicted molecular weight: 10 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.
    • 組織特異性
      T-cell and macrophage specific.
    • 配列類似性
      Belongs to the intercrine beta (chemokine CC) family.
    • 翻訳後修飾
      N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.
      The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.
    • 細胞内局在
      Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Beta chemokine RANTES antibody
      • Beta chemokine RANTES precursor antibody
      • C C motif chemokine 5 antibody
      • CCL 5 antibody
      • CCL5 antibody
      • CCL5_HUMAN antibody
      • Chemokine (C C motif) ligand 5 antibody
      • Chemokine CC Motif Ligand 5 antibody
      • D17S136E antibody
      • EoCP antibody
      • Eosinophil chemotactic cytokine antibody
      • MGC17164 antibody
      • RANTES(4-68) antibody
      • Regulated upon activation normally T expressed and presumably secreted antibody
      • SCYA 5 antibody
      • SCYA5 antibody
      • SIS delta antibody
      • SIS-delta antibody
      • SISd antibody
      • Small inducible cytokine A5 (RANTES) antibody
      • Small inducible cytokine A5 antibody
      • Small inducible cytokine subfamily A (Cys Cys) member 5 antibody
      • Small-inducible cytokine A5 antibody
      • T cell specific protein p288 antibody
      • T cell specific RANTES protein antibody
      • T cell-specific protein P228 antibody
      • T-cell-specific protein RANTES antibody
      • TCP 228 antibody
      • TCP228 antibody
      see all

    プロトコール

    参考文献

    ab83135 has not yet been referenced specifically in any publications.

    レビューと Q&A

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    The protein sequence compatibility between human and mouse with bovine is about 80% which is very close for antibody cross reactivity. We unfortunately haven't tested any of the antibody with bovine CCL5 so I am so...

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