機能Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.
配列類似性Belongs to the RANBP1 family. Contains 1 RanBD1 domain.
ab97659 at 1/200 dilution staining RanBP1 in HeLa cells by Immunofluorescence, Paraformaldehyde fixed. Lower image is merged with DNA probe.
Anti-RanBP1 antibody (ab97659) 使用論文
This product has been referenced in:
Andresen V et al. Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia. Cell Death Dis7:e2497 (2016).
Read more (PubMed: 27906185) »
Neggers JE et al. Identifying drug-target selectivity of small-molecule CRM1/XPO1 inhibitors by CRISPR/Cas9 genome editing. Chem Biol22:107-16 (2015).
Read more (PubMed: 25579209) »