製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to RanBP1
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Cow
  • 免疫原

    Synthetic peptide corresponding to Human RanBP1 aa 1-18.
    Sequence:

    MAAAKDTHEDHDTSTENT


    (Peptide available as ab4938)

  • ポジティブ・コントロール
    • HeLa cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab2937 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 24 kDa).Can be blocked with RanBP1 peptide (ab4938).

ターゲット情報

  • 機能
    Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.
  • 配列類似性
    Belongs to the RANBP1 family.
    Contains 1 RanBD1 domain.
  • Information by UniProt
  • 参照データベース
  • 別名
    • HTF9A antibody
    • RAN binding protein 1 antibody
    • Ran specific GTPase activating protein antibody
    • Ran-binding protein 1 antibody
    • Ran-specific GTPase-activating protein antibody
    • RANBP1 antibody
    • RANG_HUMAN antibody
    see all

画像

  • All lanes : Anti-RanBP1 antibody (ab2937) at 1/1000 dilution

    Lane 1 : HeLa cell lysate
    Lane 2 : Human brain tissue lysate
    Lane 3 : NIH-3T3 cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    HRP conjugated anti-rabbit
    Developed using the ECL technique

    Predicted band size : 24 kDa
    Observed band size : 27 kDa (why is the actual band size different from the predicted?)


    Exposure time : 1 minute

プロトコール

参考文献

This product has been referenced in:
  • Prpar Mihevc S  et al. TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins. Sci Rep 6:33996 (2016). WB, ICC/IF . Read more (PubMed: 27665936) »
  • Štalekar M  et al. Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport. Neuroscience 293:157-70 (2015). WB, ICC/IF . Read more (PubMed: 25743254) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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