製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to Ran
  • アプリケーション
    適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat
  • 免疫原

    Synthetic peptide:

    EHDLEVAQTTALPDEDDDL

    , corresponding to amino acids 197-216 of Human Ran

  • ポジティブ・コントロール
    • HeLa and A431 cells. Normal breast

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab31118 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent concentration. Predicted molecular weight: 24 kDa.
IHC-P 1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules.
    Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.
  • 組織特異性
    Expressed in a variety of tissues.
  • 配列類似性
    Belongs to the small GTPase superfamily. Ran family.
  • 翻訳後修飾
    The N-terminus is blocked.
  • 細胞内局在
    Nucleus. Cytoplasm. Melanosome. Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Androgen receptor associated protein 24 antibody
    • Androgen receptor-associated protein 24 antibody
    • ARA 24 antibody
    • ARA24 antibody
    • Gsp1 antibody
    • GTP binding nuclear protein RAN antibody
    • GTP-binding nuclear protein Ran antibody
    • GTPase Ran antibody
    • Guanosine triphosphatase Ran antibody
    • LPS antibody
    • OK/SW-cl.81 antibody
    • ran antibody
    • RAN member RAS oncogene family antibody
    • RAN_HUMAN antibody
    • RanGTPase antibody
    • Ras like protein TC4 antibody
    • Ras related nuclear protein antibody
    • Ras-like protein TC4 antibody
    • Ras-related nuclear protein antibody
    • RASL2 8 antibody
    • TC 4 antibody
    • TC4 antibody
    see all

画像

  • Human breast stained with ab31118 at a 1/50 dilution

参考文献

This product has been referenced in:
  • Chen WS  et al. Ran-dependent TPX2 activation promotes acentrosomal microtubule nucleation in neurons. Sci Rep 7:42297 (2017). Read more (PubMed: 28205572) »
  • Graham JD  et al. DNA replication licensing and progenitor numbers are increased by progesterone in normal human breast. Endocrinology 150:3318-26 (2009). IHC-P ; Human . Read more (PubMed: 19342456) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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