製品の概要

  • 製品名Anti-RAGE antibody [RM0127-2B65]
    RAGE 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [RM0127-2B65] to RAGE
  • アプリケーション適用あり: WB, IHC-Frmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Recombinant fragment corresponding to the extracellular domain of mouse RAGE.

  • 特記事項


    This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from an immunized rat).

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab86458 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 43 kDa.
IHC-Fr 1/50 - 1/100.

ターゲット情報

  • 機能Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.
  • 組織特異性Endothelial cells.
  • 配列類似性Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 細胞内局在Secreted and Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Advanced glycosylation end product-specific receptor antibody
    • Ager antibody
    • MGC2235 antibody
    • RAGE_HUMAN antibody
    • Receptor for advanced glycosylation end products antibody
    see all

Anti-RAGE antibody [RM0127-2B65] (ab86458) 使用論文

ab86458 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab86458.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"