製品の概要

  • 製品名Anti-Rad9 antibody
    Rad9 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Rad9
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Cow, Dog, Pig, Ferret, Rhesus monkey, Gorilla, Bat
  • 免疫原

    Synthetic peptide corresponding to a region between residue 350 and the C-terminus (residue 391) of Human Rad9 (NP_004575.1).

  • ポジティブ・コントロール
    • Human Breast Carcinoma, Prostate Carcinoma

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab84912 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.
    • 配列類似性Belongs to the rad9 family.
    • 翻訳後修飾Constitutively phosphorylated on serine and threonine amino acids in absence of DNA damage. Hyperphosphorylated by PRKCD and ABL1 upon DNA damage. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.
    • 細胞内局在Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Cell cycle checkpoint control protein antibody
      • Cell cycle checkpoint control protein RAD9A antibody
      • DNA repair exonuclease rad9 homolog A antibody
      • hRAD 9 antibody
      • hRAD9 antibody
      • Rad 9 antibody
      • RAD 9A antibody
      • RAD9 (S pombe) homolog antibody
      • RAD9 homolog A antibody
      • RAD9 homolog antibody
      • Rad9a antibody
      • RAD9A_HUMAN antibody
      see all

    Anti-Rad9 antibody 画像

    • ab84912, at 1/250 dilution, staining Rad9 in formalin-fixed, paraffin-embedded human prostate carcinoma by Immunohistochemistry using DAB staining.
    • ab84912, at 1/250 dilution, staining Rad9 in formalin-fixed, paraffin-embedded human breast carcinoma by Immunohistochemistry using a Red-fluorescent goat anti-rabbit IgG highly cross-adsorbed Hilyte PlusTM 555 secondary antibody at a dilution of 1/100.

    Anti-Rad9 antibody (ab84912) 使用論文

    ab84912 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab84912.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"