Anti-RAB7L1 抗体 (ab101394)

製品の概要

• 製品名
  Anti-RAB7L1 antibody
  RAB7L1 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to RAB7L1
• アプリケーション
  適用あり: WBmore details
• 種交差性
  交差種: Human
  交差が予測される動物種: Mouse, Rat, Cow
• 免疫原

  Recombinant protein fragment containing a sequence corresponding to a region within amino acids 53 and 199 of RAB7L1 (AAH02585).

• ポジティブ･コントロール
  • A431 and Raji cell lysates

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• バッファー
  Preservative: 0.01% Thimerosal (merthiolate)
  Constituents: 20% Glycerol, 1% BSA, PBS, pH 7.0
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Signal Transduction
  • Signaling Pathway
  • G Protein Signaling
  • Small G Proteins
  • Ras Family

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • A431 whole cell lysate (ab7909)

アプリケーション

ターゲット情報

• 機能
  Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.
• 組織特異性
  Ubiquitous.
• 配列類似性
  Belongs to the small GTPase superfamily. Rab family.
• 翻訳後修飾
  In case of Salmonella enterica serovar Typhimurium (S.Typhimurium) infection, is proteolytically cleaved between Gly-41 and Val-42 by the GtgE viral protease encoded on the Gifsy-2 lysogen bacteriophage, which therefore prevents the recruitment of RAB29 to S.Typhimurium-containing vacuoles. In contrast, no proteolytically cleavage is detected in S.Typhi-infected cells (PubMed:22042847).
• 細胞内局在
  Cell membrane. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Vacuole. Cytoplasm, cytoskeleton. Colocalizes with LRRK2 along tubular structures emerging from Golgi apparatus (By similarity). Colocalizes with GM130 at the Golgi apparatus. Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus. Colocalizes with TGN46 at the trans-Golgi network (TGN). In Salmonella enterica serovar Typhi (S.Typhi) infected epithelial cells, is recruited and colocalized with both S.Typhi-containing vacuoles and dynamic tubules as well as those emerging from the vacuole toward the cell periphery.

• Target information above from: UniProt accession O14966 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 8934 Human
  • Entrez Gene: 226422 Mouse
  • Entrez Gene: 171122 Rat
  • Omim: 603949 Human
  • SwissProt: O14966 Human
  • SwissProt: Q91YQ1 Mouse
  • SwissProt: Q63481 Rat
  • Unigene: 115325 Human

  • Unigene: 34027 Mouse
  • Unigene: 4323 Rat

  see all
• 別名
  • DKFZp686P1051 antibody
  • Rab 7 like protein 1 antibody
  • RAB 7L antibody

  • Rab-7-like protein 1 antibody
  • RAB29 antibody
  • Rab7 like protein 1 antibody
  • RAB7 member RAS oncogene family like 1 antibody
  • RAB7L antibody
  • RAB7L_HUMAN antibody
  • Ras related protein Rab 7L1 antibody
  • Ras related protein Rab7L1 antibody
  • Ras-related protein Rab-29 antibody
  • Ras-related protein Rab-7L1 antibody

  see all

プロトコール

• Western blot protocols