製品の概要

  • 製品名Anti-RAB7L1 antibody
    RAB7L1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to RAB7L1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow
  • 免疫原

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 53 and 199 of RAB7L1 (AAH02585).

  • ポジティブ・コントロール
    • A431 and Raji cell lysates

法規制情報

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.01% Thimerosal (merthiolate)
    Constituents: 20% Glycerol, 1% BSA, PBS, pH 7.0
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab101394 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 23 kDa.

ターゲット情報

  • 機能Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.
  • 組織特異性Ubiquitous.
  • 配列類似性Belongs to the small GTPase superfamily. Rab family.
  • 翻訳後修飾In case of Salmonella enterica serovar Typhimurium (S.Typhimurium) infection, is proteolytically cleaved between Gly-41 and Val-42 by the GtgE viral protease encoded on the Gifsy-2 lysogen bacteriophage, which therefore prevents the recruitment of RAB29 to S.Typhimurium-containing vacuoles. In contrast, no proteolytically cleavage is detected in S.Typhi-infected cells (PubMed:22042847).
  • 細胞内局在Cell membrane. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Vacuole. Cytoplasm, cytoskeleton. Colocalizes with LRRK2 along tubular structures emerging from Golgi apparatus (By similarity). Colocalizes with GM130 at the Golgi apparatus. Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus. Colocalizes with TGN46 at the trans-Golgi network (TGN). In Salmonella enterica serovar Typhi (S.Typhi) infected epithelial cells, is recruited and colocalized with both S.Typhi-containing vacuoles and dynamic tubules as well as those emerging from the vacuole toward the cell periphery.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DKFZp686P1051 antibody
    • Rab 7 like protein 1 antibody
    • RAB 7L antibody
    • Rab-7-like protein 1 antibody
    • RAB29 antibody
    • Rab7 like protein 1 antibody
    • RAB7 member RAS oncogene family like 1 antibody
    • RAB7L antibody
    • RAB7L_HUMAN antibody
    • Ras related protein Rab 7L1 antibody
    • Ras related protein Rab7L1 antibody
    • Ras-related protein Rab-29 antibody
    • Ras-related protein Rab-7L1 antibody
    see all

Anti-RAB7L1 antibody 画像

  • Anti-RAB7L1 antibody (ab101394) at 1/500 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 23 kDa

Anti-RAB7L1 antibody (ab101394) 使用論文

ab101394 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"