製品の概要

  • 製品名Anti-RAB27A antibody
    RAB27A 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to RAB27A
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 171-220 (SQAIEMLLDL IMKRMERCVD KSWIPEGVVR SNGHASTDQL SEEKEKGACG) of Human RAB27A (NP_004571).

  • ポジティブ・コントロール
    • Human fetal stomach lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab98339 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 25 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.
  • 組織特異性Found in all the examined tissues except in brain. Low expression was found in thymus, kidney, muscle and placenta. Detected in melanocytes, and in most tumor cell lines examined. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.
  • 関連疾患Defects in RAB27A are a cause of Griscelli syndrome type 2 (GS2) [MIM:607624]. Griscelli syndrome is a rare autosomal recessive disorder that results in pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes. GS2 patients also develop an uncontrolled T-lymphocyte and macrophage activation syndrome, known as hemophagocytic syndrome, leading to death in the absence of bone marrow transplantation. Neurological impairment is present in some patients, likely as a result of hemophagocytic syndrome.
  • 配列類似性Belongs to the small GTPase superfamily. Rab family.
  • 細胞内局在Membrane. Melanosome. Late endosome. Lysosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles.
  • Information by UniProt
  • 参照データベース
  • 別名
    • GS2 antibody
    • GTP-binding protein Ram antibody
    • HsT18676 antibody
    • MGC117246 antibody
    • Mutant Ras related protein Rab-27A antibody
    • Rab-27 antibody
    • RAB-27A antibody
    • RAB27 antibody
    • RAB27A antibody
    • RAB27A member RAS oncogene family antibody
    • RAM antibody
    • Ras-related protein Rab-27A antibody
    • Ras-related protein Rab27A antibody
    • RB27A_HUMAN antibody
    see all

Anti-RAB27A antibody 画像

  • Anti-RAB27A antibody (ab98339) at 1 µg/ml + Human fetal stomach lysate at 10 µg

    Predicted band size : 25 kDa

Anti-RAB27A antibody (ab98339) 使用論文

ab98339 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"