製品の概要

  • 製品名Anti-RAB27A antibody
    RAB27A 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to RAB27A
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Recombinant fragment, corresponding to amino acids 1-215 of Human RAB27A (BC132800).

  • ポジティブ・コントロール
    • HEK293 cell lysate; Human fetal skin lysate.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab124325 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 25 kDa.

ターゲット情報

  • 機能Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.
  • 組織特異性Found in all the examined tissues except in brain. Low expression was found in thymus, kidney, muscle and placenta. Detected in melanocytes, and in most tumor cell lines examined. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.
  • 関連疾患Defects in RAB27A are a cause of Griscelli syndrome type 2 (GS2) [MIM:607624]. Griscelli syndrome is a rare autosomal recessive disorder that results in pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes. GS2 patients also develop an uncontrolled T-lymphocyte and macrophage activation syndrome, known as hemophagocytic syndrome, leading to death in the absence of bone marrow transplantation. Neurological impairment is present in some patients, likely as a result of hemophagocytic syndrome.
  • 配列類似性Belongs to the small GTPase superfamily. Rab family.
  • 細胞内局在Membrane. Melanosome. Late endosome. Lysosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles.
  • Information by UniProt
  • 参照データベース
  • 別名
    • GS2 antibody
    • GTP-binding protein Ram antibody
    • HsT18676 antibody
    • MGC117246 antibody
    • Mutant Ras related protein Rab-27A antibody
    • Rab-27 antibody
    • RAB-27A antibody
    • RAB27 antibody
    • RAB27A antibody
    • RAB27A member RAS oncogene family antibody
    • RAM antibody
    • Ras-related protein Rab-27A antibody
    • Ras-related protein Rab27A antibody
    • RB27A_HUMAN antibody
    see all

Anti-RAB27A antibody 画像

  • All lanes : Anti-RAB27A antibody (ab124325) at 1/500 dilution

    Lane 1 : HEK293 cell lysate.
    Lane 2 : Human fetal skin lysate.


    Predicted band size : 25 kDa

Anti-RAB27A antibody (ab124325) 使用論文

ab124325 has not yet been referenced specifically in any publications.

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