R-(-)-α-Methylhistamine dihydrobromide (ab120774)

製品の概要

  • 製品名R-(-)-α-Methylhistamine dihydrobromide
  • 製品の詳細
    Highly potent, selective H3 receptor agonist
  • 生理活性の詳細Highly potent, selective H3 receptor agonist (Kd = 50 nM). Induces H4-mediated eosinophil shape change (EC50 = 66 nM). Inhibits H3-mediated histamine synthesis and release in the CNS. Active in vivo.
  • 精製度> 99%

製品の特性

  • 体系名1-(1H-Imidazol-5-yl)propan-2-amine dihydrobromide
  • 分子量287.00
  • 構造式Chemical Structure
  • 分子式C6H11N3.2HBr
  • CAS 番号75614-87-8
  • PubChem 登録番号206868
  • 保存方法Store at Room Temperature. The product can be stored for up to 12 months.
  • 溶解性Soluble in water to 100 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記CC(CC1=CN=CN1)N.Br.Br
  • 由来

    Synthetic

  • 研究分野

    R-(-)-α-Methylhistamine dihydrobromide (ab120774) 使用論文

    This product has been referenced in:
    • Francis H  et al. H3 histamine receptor-mediated activation of protein kinase Calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo. Mol Cancer Res 7:1704-13 (2009). Read more (PubMed: 19825989) »
    • Francis H  et al. H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway. Lab Invest 87:473-87 (2007). Read more (PubMed: 17334413) »
    • Oishi R  et al. Effects of the histamine H3-agonist (R)-alpha-methylhistamine and the antagonist thioperamide on histamine metabolism in the mouse and rat brain. J Neurochem 52:1388-92 (1989). Read more (PubMed: 2540269) »

    See 0 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120774.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"