QX-314 chloride (N-Ethyllidocaine chloride), Na+ channel blocker (ab120118)
Key features and details
- Na+ channel blocker
- CAS Number: 5369-03-9
- Soluble in water to 100 mM and to 50 mM in DMSO
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
QX-314 chloride (N-Ethyllidocaine chloride), Na+ channel blocker -
製品の詳細
Na+ channel blocker -
別名
- N-Ethyllidocaine chloride
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生理活性の詳細
A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ channels.
Also available in simple stock solutions (ab144493) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS 番号
5369-03-9 -
構造式
製品の特性
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体系名
N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride -
分子量
298.85 -
分子式
C16H27ClN2O -
PubChem 登録番号
21462 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 100 mM and to 50 mM in DMSO -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
[Cl-].O=C(Nc1c(C)cccc1C)C[N+](CC)(CC)CC -
由来
Synthetic
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研究分野
画像
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (15)
ab120118 は 15 報の論文で使用されています。
- Biane C et al. Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons. Elife 10:N/A (2021). PubMed: 34730085
- Weyrer C et al. Introduction of synaptotagmin 7 promotes facilitation at the climbing fiber to Purkinje cell synapse. Cell Rep 36:109719 (2021). PubMed: 34551307
- Vaden RJ et al. Parvalbumin interneurons provide spillover to newborn and mature dentate granule cells. Elife 9:N/A (2020). PubMed: 32602839
- Rudolph S et al. Cerebellum-Specific Deletion of the GABAA Receptor d Subunit Leads to Sex-Specific Disruption of Behavior. Cell Rep 33:108338 (2020). PubMed: 33147470
- Hoehne A et al. Feed-forward recruitment of electrical synapses enhances synchronous spiking in the mouse cerebellar cortex. Elife 9:N/A (2020). PubMed: 32990593