製品の概要

  • 製品名Quinacrine dihydrochloride
  • 製品の詳細
    Non-selective phospholipase A2 inhibitor
  • 別名
    • Atebrine
    • Mepacrine
  • 生理活性の詳細Non-selective phospholipase A2 inhibitor (PLA2). IC50 = 200 μM for bovine brain cPLA2. Neuroprotective properties. Centrally active upon intraperitoneal administration.
  • 精製度> 98%
  • 特記事項

    This product is reported to be light sensitive

製品の特性

  • 体系名N4-(6-Chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-1,4-pentanediamine dihydrochloride
  • 分子量472.88
  • 構造式Chemical Structure
  • 分子式C23H30ClN3O.2HCl
  • CAS 番号69-05-6
  • 保存方法Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性Soluble in water to 100 mM (with warming)
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • 由来

    Synthetic

  • 研究分野

    Quinacrine dihydrochloride (ab120749) 使用論文

    This product has been referenced in:
    • Ong WY  et al. Quinacrine abolishes increases in cytoplasmic phospholipase A2 mRNA levels in the rat hippocampus after kainate-induced neuronal injury. Exp Brain Res 148:521-4 (2003). Read more (PubMed: 12582837) »
    • Lu XR  et al. Differential effects of calcium-dependent and calcium-independent phospholipase A(2) inhibitors on kainate-induced neuronal injury in rat hippocampal slices. Free Radic Biol Med 30:1263-73 (2001). Read more (PubMed: 11368924) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"