製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to QKI
  • アプリケーション
    適用あり: IHC-P, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Cow, Cat
  • 免疫原

    Recombinant fragment within Human QKI aa 156-317. The exact sequence is proprietary.
    Database link: AAH19917

  • ポジティブ・コントロール
    • 293T whole cell lysate, MDA-MB157 xenograft.

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab102086 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/100 - 1/500.
WB 1/500 - 1/3000. Predicted molecular weight: 38 kDa.

ターゲット情報

  • 機能
    RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor.
  • 組織特異性
    Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients.
  • 配列類似性
    Contains 1 KH domain.
  • ドメイン
    The KH domain and the Qua2 region are involved in RNA binding.
  • 翻訳後修飾
    Methylated by PRMT1.
    Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA.
  • 細胞内局在
    Nucleus. Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DKFZp586I0923 antibody
    • HKQ antibody
    • Homolog of mouse quaking QKI KH domain RNA binding protein antibody
    • Hqk antibody
    • HQK1 antibody
    • HqkI antibody
    • OTTHUMP00000017581 antibody
    • OTTHUMP00000017582 antibody
    • OTTHUMP00000017583 antibody
    • Protein quaking antibody
    • QK antibody
    • QK1 antibody
    • QK3 antibody
    • QKI antibody
    • QKI_HUMAN antibody
    • QKI1 antibody
    • Quaking homolog antibody
    • Quaking homolog KH domain RNA binding antibody
    • Quaking homolog KH domain RNA binding mouse antibody
    • Quaking isoform 1 antibody
    • Quaking protein antibody
    • RNA binding protein HQK antibody
    see all

画像

  • Anti-QKI antibody (ab102086) at 1/1000 dilution + 293T whole cell lysate at 30 µg

    Predicted band size : 38 kDa
    10% SDS PAGE
  • Immunohistochemical analysis of paraffin-embedded MDA-MB157 xenograft, using ab102086 at 1/100 dilution.

参考文献

ab102086 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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