製品の概要

  • 製品名
    Pumilio 2 peptide (141-155)

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      C-DQNRDLKQGDDDDSK
    • 領域
      141 to 155

関連製品

特性

Our Abpromise guarantee covers the use of ab45710 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-Pumilio 2 antibody (ab32894)

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

関連情報

  • 別名
    • FLJ36528
    • KIAA0235
    • MGC138251
    • MGC138253
    • PUM 2
    • PUM2
    • PUM2_HUMAN
    • PUMH 2
    • PUMH2
    • Pumilio (Drosphila) homolog 2
    • Pumilio homolog 2
    • Pumilio homolog 2 (Drosophila)
    • Pumilio-2
    • Pumilio2
    • PUML2
    see all
  • 機能
    Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts.
  • 組織特異性
    Expressed in male germ cells of adult testis (at protein level). Highly expressed in testis and ovary. Predominantly expressed in stem cells and germ cells. Expressed at lower level in brain, heart, kidney, liver, muscle, placenta, intestine and stomach Expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested.
  • 配列類似性
    Contains 1 PUM-HD domain.
    Contains 8 pumilio repeats.
  • ドメイン
    The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half doughnut. The number as well as the specific sequence of the repeats determine the specificity for target mRNAs.
  • 細胞内局在
    Cytoplasm. Cytoplasmic granule. Cytoplasm > perinuclear region. The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Colocalizes with NANOS1 and SNAPIN in the perinuclear region of germ cells.
  • Information by UniProt

参考文献

ab45710 has not yet been referenced specifically in any publications.

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