Anti-PTS (phospho S19) 抗体 [EPR1517(2)] (ab109462)


  • 製品名Anti-PTS (phospho S19) antibody [EPR1517(2)]
    PTS 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR1517(2)] to PTS (phospho S19)
  • 特異性ab109462 only detects PTS phosphorylated at Serine 19.
  • アプリケーション適用あり: WB, IP, IHC-P, ICC/IFmore details
    適用なし: Flow Cyt
  • 種交差性
    交差種: Human
  • 免疫原

    A phospho specific peptide corresponding to residues surrounding Serine 19 of Human PTS.

  • ポジティブ・コントロール
    • HUVEC cell lysates; Human brain tissue; HeLa cells
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.



Our Abpromise guarantee covers the use of ab109462 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/10000. Detects a band of approximately 17 kDa (predicted molecular weight: 16 kDa).
IP 1/10 - 1/100.
IHC-P 1/250 - 1/500. Heat up to 98 °C, below boiling, and then let cool for 10-20 minutes.
ICC/IF 1/250 - 1/500.
  • 追加情報Is unsuitable for Flow Cyt.
  • ターゲット情報

    • 機能Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
    • パスウェイCofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.
    • 関連疾患Defects in PTS are the cause of BH4-deficient hyperphenylalaninemia type A (HPABH4A) [MIM:261640]; also called 6-pyruvoyl-tetrahydropterin synthase deficiency (PTS deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to PTS deficiency. HPABH4A is an autosomal recessive disorder characterized by depletion of the neurotransmitters dopamine and serotonin, and clinically by severe neurological symptoms unresponsive to the classic phenylalanine-low diet.
    • 配列類似性Belongs to the PTPS family.
    • 翻訳後修飾Phosphorylation of Ser-19 is required for maximal enzyme activity.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 6 pyruvoyl tetrahydrobiopterin synthase antibody
      • 6 pyruvoyl tetrahydropterin synthase antibody
      • 6 pyruvoyltetrahydropterin synthase antibody
      • 6-pyruvoyl tetrahydrobiopterin synthase antibody
      • EC antibody
      • FLJ97081 antibody
      • OTTHUMP00000235385 antibody
      • PTP synthase antibody
      • PTPS antibody
      • PTPS_HUMAN antibody
      • PTS antibody
      see all

    Anti-PTS (phospho S19) antibody [EPR1517(2)] 画像

    • All lanes : Anti-PTS (phospho S19) antibody [EPR1517(2)] (ab109462) at 1/1000 dilution

      Lane 1 : HUVEC cell lysates
      Lane 2 : HUVEC cell lysates treated with Alkaline Phosphatase

      Lysates/proteins at 10 µg per lane.

      HRP-labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 16 kDa
      Observed band size : 17 kDa (why is the actual band size different from the predicted?)
    • ab109462, at a 1/250 dilution, staining PTS (phospho S19) in paraffin embedded Human brain tissue by Immunohistochemistry.
    • ab109462, at a 1/250 dilution, staining PTS (phospho S19) in HeLa cells by Immunofluorescence.

    Anti-PTS (phospho S19) antibody [EPR1517(2)] (ab109462) 使用論文

    ab109462 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab109462.
    Please use the links above to contact us or submit feedback about this product.