製品の概要

  • 製品名Anti-PTPRB antibody [122.2]
  • 製品の詳細
    Mouse monoclonal [122.2] to PTPRB
  • 特異性This antibody is specific for Receptor Tyrosine Phosphatase Beta (phosphacan).
  • アプリケーション適用あり: WB, ICC/IF, ICC, IPmore details
  • 種交差性
    交差種: Rat
  • 免疫原

    Embryonic rat brain proteoglycans.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファーPreservative: None
    Constituents: PBS
  • Concentration information loading...
  • 特記事項(精製)Concentrated antibody. This antibody was grown in protein free medium, then concentrated snd dialysed against PBS.
  • ポリ/モノモノクローナル
  • クローン名122.2
  • アイソタイプIgM
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab31654 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/2500. Predicted molecular weight: 224 kDa.
ICC/IF Use at an assay dependent dilution.
ICC Use at an assay dependent dilution.
IP Use at an assay dependent dilution.

ターゲット情報

  • 機能Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin.
  • 配列類似性Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
    Contains 17 fibronectin type-III domains.
    Contains 1 tyrosine-protein phosphatase domain.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 別名
    • HPTP BETA antibody
    • HPTPB antibody
    • Phosphacan receptor type B antibody
    • Protein tyrosine phosphatase receptor type B antibody
    • Protein-tyrosine phosphatase beta antibody
    • PTPB antibody
    • Ptprb antibody
    • PTPRB_HUMAN antibody
    • R PTP BETA antibody
    • R-PTP-beta antibody
    • Receptor-type tyrosine-protein phosphatase beta antibody
    • RPTPB antibody
    • Vascular endothelial protein tyrosine phosphatase antibody
    • VE-PTP antibody
    see all

Anti-PTPRB antibody [122.2] (ab31654) 使用論文

ab31654 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"