製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to PTP4A3
  • アプリケーション
    適用あり: WB, IHC-P, IP, ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide:

    FKDPHTHKTR

    conjugated to KLH by an N-terminal Cysteine residue linker, corresponding to amino acids 160-169 of Human PTP4A3

  • ポジティブ・コントロール
    • Whole extract of human HepG2 cells, protease digested formalin-fixed, paraffin-embedded human heart sections and recombinant human PRL-3.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファー
    Preservative: 15mM Sodium Azide
    Constituents: 0.01M PBS, pH 7.4
  • Concentration information loading...
  • 精製度
    IgG fraction
  • 特記事項(精製)
    Whole antiserum is fractionated and then further purified by ion-exchange chromatography to provide the IgG fraction of antiserum that is essentially free of other rabbit serum proteins.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab50276 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 19 kDa. Staining can be inhibited by the immunizing peptide.
IHC-P 1/250 - 1/500.
IP Use a concentration of 0.5 - 1 µg/ml.
ICC/IF Use at an assay dependent concentration. PubMed: 22345654

ターゲット情報

  • 機能
    Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
  • 組織特異性
    Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
  • 配列類似性
    Belongs to the protein-tyrosine phosphatase family.
    Contains 1 tyrosine-protein phosphatase domain.
  • 翻訳後修飾
    Farnesylated. Farnesylation is required for membrane targeting.
  • 細胞内局在
    Cell membrane. Early endosome.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Potentially prenylated protein tyrosine phosphatase antibody
    • PRL 3 antibody
    • PRL R antibody
    • PRL-3 antibody
    • PRL-R antibody
    • PRL3 antibody
    • PRLR antibody
    • Protein tyrosine phosphatase 4a3 antibody
    • Protein tyrosine phosphatase type IVA 3 antibody
    • Protein-tyrosine phosphatase 4a3 antibody
    • Protein-tyrosine phosphatase of regenerating liver 3 antibody
    • PTP 4A3 antibody
    • PTP4A3 antibody
    • TP4A3_HUMAN antibody
    see all

Anti-PTP4A3 antibody (ab50276) 使用論文

This product has been referenced in:
  • Xing C  et al. Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis. Cancer Res 76:83-95 (2016). Read more (PubMed: 26669864) »
  • Xiong J  et al. PRL-3 promotes the peritoneal metastasis of gastric cancer through the PI3K/Akt signaling pathway by regulating PTEN. Oncol Rep 36:1819-28 (2016). WB ; Human . Read more (PubMed: 27572739) »

See all 6 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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