製品の概要

  • 製品名Anti-PTP4A3 antibody
    PTP4A3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PTP4A3
  • 特異性ab50276 recognizes human PRL-3 and does not cross-react with human PRL-1 and PRL-2.
  • アプリケーション適用あり: WB, IHC-P, IP, ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide:

    FKDPHTHKTR

    conjugated to KLH by an N-terminal Cysteine residue linker, corresponding to amino acids 160-169 of Human PTP4A3

  • ポジティブ・コントロール
    • Whole extract of human HepG2 cells, protease digested formalin-fixed, paraffin-embedded human heart sections and recombinant human PRL-3.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab50276 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 19 kDa. Staining can be inhibited by the immunizing peptide.
IHC-P 1/250 - 1/500.
IP Use a concentration of 0.5 - 1 µg/ml.
ICC/IF Use at an assay dependent concentration. PubMed: 22345654

ターゲット情報

  • 機能Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
  • 組織特異性Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
  • 配列類似性Belongs to the protein-tyrosine phosphatase family.
    Contains 1 tyrosine-protein phosphatase domain.
  • 翻訳後修飾Farnesylated. Farnesylation is required for membrane targeting.
  • 細胞内局在Cell membrane. Early endosome.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Potentially prenylated protein tyrosine phosphatase antibody
    • PRL 3 antibody
    • PRL R antibody
    • PRL-3 antibody
    • PRL-R antibody
    • PRL3 antibody
    • PRLR antibody
    • Protein tyrosine phosphatase 4a3 antibody
    • Protein tyrosine phosphatase type IVA 3 antibody
    • Protein-tyrosine phosphatase 4a3 antibody
    • Protein-tyrosine phosphatase of regenerating liver 3 antibody
    • PTP 4A3 antibody
    • PTP4A3 antibody
    • TP4A3_HUMAN antibody
    see all

Anti-PTP4A3 antibody (ab50276) 使用論文

This product has been referenced in:
  • Xing C  et al. Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis. Cancer Res 76:83-95 (2016). Read more (PubMed: 26669864) »
  • Mayinuer A  et al. Upregulation of protein tyrosine phosphatase type IVA member 3 (PTP4A3/PRL-3) is associated with tumor differentiation and a poor prognosis in human hepatocellular carcinoma. Ann Surg Oncol 20:305-17 (2013). IHC-P ; Human . Read more (PubMed: 23064776) »

See all 5 Publications for this product

Product Wall

Thank you for taking the time to complete our questionnaire and contact us. I am sorry to hear you have had difficulty obtaining satisfactory results from this antibody. The details you have kindly provided will enable us to investigate this case f...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"