Anti-PTP4A3/PRL-R 抗体 (ab50276)
Key features and details
- Rabbit polyclonal to PTP4A3/PRL-R
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-PTP4A3/PRL-R antibody
PTP4A3/PRL-R 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to PTP4A3/PRL-R -
由来種
Rabbit -
アプリケーション
適用あり: IHC-P, WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse -
免疫原
Synthetic peptide corresponding to Human PTP4A3/PRL-R aa 150-250 conjugated to keyhole limpet haemocyanin (Cysteine residue).
Database link: O75365 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Preservative: 0.097% Sodium azide
Constituent: 0.0268% PBS -
Concentration information loading...
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精製度
IgG fraction -
特記事項(精製)
Whole antiserum is fractionated and then further purified by ion-exchange chromatography to provide the IgG fraction of antiserum that is essentially free of other rabbit serum proteins. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab50276の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
1/250 - 1/500.
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WB |
1/500 - 1/1000. Predicted molecular weight: 25 kDa.
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特記事項 |
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IHC-P
1/250 - 1/500. |
WB
1/500 - 1/1000. Predicted molecular weight: 25 kDa. |
ターゲット情報
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機能
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. -
組織特異性
Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis. -
配列類似性
Belongs to the protein-tyrosine phosphatase family.
Contains 1 tyrosine-protein phosphatase domain. -
翻訳後修飾
Farnesylated. Farnesylation is required for membrane targeting. -
細胞内局在
Cell membrane. Early endosome. - Information by UniProt
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参照データベース
- Entrez Gene: 11156 Human
- Entrez Gene: 19245 Mouse
- Omim: 606449 Human
- SwissProt: O75365 Human
- SwissProt: Q9D658 Mouse
- Unigene: 43666 Human
- Unigene: 744870 Human
- Unigene: 390807 Mouse
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別名
- Potentially prenylated protein tyrosine phosphatase antibody
- PRL 3 antibody
- PRL R antibody
see all
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (12)
ab50276 は 12 報の論文で使用されています。
- Zhou Q et al. PRL-3 facilitates Hepatocellular Carcinoma progression by co-amplifying with and activating FAK. Theranostics 10:10345-10359 (2020). PubMed: 32929353
- Edwards DR et al. PRL-3 increases the aggressive phenotype of prostate cancer cells in vitro and its expression correlates with high-grade prostate tumors in patients. Int J Oncol 52:402-412 (2018). PubMed: 29207031
- Zhang Y et al. PRL-3 promotes gastric cancer peritoneal metastasis via the PI3K/AKT signaling pathway in vitro and in vivo. Oncol Lett 15:9069-9074 (2018). PubMed: 29805638
- Xie H & Wang H PRL-3 promotes breast cancer progression by downregulating p14ARF-mediated p53 expression. Oncol Lett 15:2795-2800 (2018). PubMed: 29435006
- Li BH et al. Up-Regulation of Phosphatase in Regenerating Liver-3 (PRL-3) Contributes to Malignant Progression of Hepatocellular Carcinoma by Activating Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN)/Phosphoinositide 3-Kinase (PI3K)/AKT Signaling Pathway. Med Sci Monit 24:8105-8114 (2018). PubMed: 30418964