製品の概要
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製品名Anti-PTP4A3 antibody
PTP4A3 一次抗体 製品一覧 -
製品の詳細Rabbit polyclonal to PTP4A3
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由来種Rabbit
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アプリケーション適用あり: WB, ELISAmore details
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種交差性交差種: Human
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免疫原
Recombinant full length protein (Human)
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
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バッファーPreservative: None
Constituents: Whole serum -
精製度Whole antiserum
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab26947 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | 1/5000. Predicted molecular weight: 19 kDa. | |
| ELISA | 1/100000. |
ターゲット情報
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機能Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
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組織特異性Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
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配列類似性Belongs to the protein-tyrosine phosphatase family.
Contains 1 tyrosine-protein phosphatase domain. -
翻訳後修飾Farnesylated. Farnesylation is required for membrane targeting.
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細胞内局在Cell membrane. Early endosome.
- Information by UniProt
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参照データベース
- Entrez Gene: 11156 Human
- Omim: 606449 Human
- SwissProt: O75365 Human
- Unigene: 43666 Human
- Unigene: 744870 Human
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別名
- Potentially prenylated protein tyrosine phosphatase antibody
- PRL 3 antibody
- PRL R antibody
see all
画像
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Western blot - Anti-PTP4A3 antibody (ab26947)All lanes : Anti-PTP4A3 antibody (ab26947) at 1/5000 dilution
Lane 1 : (T2.5) IPTG induction of the recombinant protein expression for 2.5 hours.
Lane 2 : (T0) before IPTG induction of the protein expression
Predicted band size: 19 kDa
Observed band size: 23.9 kDa (why is the actual band size different from the predicted?)
プロトコール
参考文献
This product has been referenced in:
- Laurent C et al. High PTP4A3 Phosphatase Expression Correlates with Metastatic Risk in Uveal Melanoma Patients. Cancer Res 71:666-74 (2011). WB ; Human . Read more (PubMed: 21135111) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"