製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to PTP4A3
  • アプリケーション
    適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length protein (Human)

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab26947 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/5000. Predicted molecular weight: 19 kDa.
ELISA 1/100000.

ターゲット情報

  • 機能
    Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
  • 組織特異性
    Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
  • 配列類似性
    Belongs to the protein-tyrosine phosphatase family.
    Contains 1 tyrosine-protein phosphatase domain.
  • 翻訳後修飾
    Farnesylated. Farnesylation is required for membrane targeting.
  • 細胞内局在
    Cell membrane. Early endosome.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Potentially prenylated protein tyrosine phosphatase antibody
    • PRL 3 antibody
    • PRL R antibody
    • PRL-3 antibody
    • PRL-R antibody
    • PRL3 antibody
    • PRLR antibody
    • Protein tyrosine phosphatase 4a3 antibody
    • Protein tyrosine phosphatase type IVA 3 antibody
    • Protein-tyrosine phosphatase 4a3 antibody
    • Protein-tyrosine phosphatase of regenerating liver 3 antibody
    • PTP 4A3 antibody
    • PTP4A3 antibody
    • TP4A3_HUMAN antibody
    see all

画像

  • All lanes : Anti-PTP4A3 antibody (ab26947) at 1/5000 dilution

    Lane 1 : (T2.5) IPTG induction of the recombinant protein expression for 2.5 hours.
    Lane 2 : (T0) before IPTG induction of the protein expression


    Predicted band size : 19 kDa
    Observed band size : 23.9 kDa (why is the actual band size different from the predicted?)

プロトコール

参考文献

This product has been referenced in:
  • Laurent C  et al. High PTP4A3 Phosphatase Expression Correlates with Metastatic Risk in Uveal Melanoma Patients. Cancer Res 71:666-74 (2011). WB ; Human . Read more (PubMed: 21135111) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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