製品の概要

  • 製品名
    Anti-PTP4A3 antibody [111AT714]
    PTP4A3 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [111AT714] to PTP4A3
  • アプリケーション
    適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Recombinant full length protein corresponding to Mouse PTP4A3.

  • ポジティブ・コントロール
    • WB: 293 cells transfected with PTP4A3.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab38673 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 20 kDa.
ICC/IF Use at an assay dependent concentration. PubMed: 19586538

ターゲット情報

  • 機能
    Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
  • 組織特異性
    Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
  • 配列類似性
    Belongs to the protein-tyrosine phosphatase family.
    Contains 1 tyrosine-protein phosphatase domain.
  • 翻訳後修飾
    Farnesylated. Farnesylation is required for membrane targeting.
  • 細胞内局在
    Cell membrane. Early endosome.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Potentially prenylated protein tyrosine phosphatase antibody
    • PRL 3 antibody
    • PRL R antibody
    • PRL-3 antibody
    • PRL-R antibody
    • PRL3 antibody
    • PRLR antibody
    • Protein tyrosine phosphatase 4a3 antibody
    • Protein tyrosine phosphatase type IVA 3 antibody
    • Protein-tyrosine phosphatase 4a3 antibody
    • Protein-tyrosine phosphatase of regenerating liver 3 antibody
    • PTP 4A3 antibody
    • PTP4A3 antibody
    • TP4A3_HUMAN antibody
    see all

画像

  • Anti-PTP4A3 antibody [111AT714] (ab38673) at 1/100 dilution + 293 cells transfected with PTP4A3 at 35 µg

    Predicted band size : 20 kDa
    Observed band size : 20 kDa

参考文献

This product has been referenced in:
  • Molleví DG  et al. PRL-3 overexpression in epithelial cells is induced by surrounding stromal fibroblasts. Mol Cancer 8:46 (2009). ICC/IF ; Human . Read more (PubMed: 19586538) »

See 1 Publication for this product

レビューと Q&A

Application
Western blot
Sample
Human Recombinant protein (COS7 extract expressing both HA-tagged and no-tag)
Loading amount
20 µg
Specification
COS7 extract expressing both HA-tagged and no-tag
Gel Running Conditions
Reduced Denaturing (15 % SDS-PAG)
Blocking step
Blocking One as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 100%
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投稿 Apr 17 2009

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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