Anti-PTP1B (phospho S50) 抗体 [EP1838Y] (ab62320)

製品の概要

• 製品名
  Anti-PTP1B (phospho S50) antibody [EP1838Y]
  PTP1B 一次抗体 製品一覧
• 製品の詳細
  Rabbit monoclonal [EP1838Y] to PTP1B (phospho S50)
• 特異性
  This antibody detects PTP1B when phosphorylated at Serine 50.
• アプリケーション
  適用あり: WBmore details
• 種交差性
  交差種: Human
  
• 免疫原

  A phospho specific peptide corresponding to residues surround Serine 50 of human PTP1B.

• ポジティブ･コントロール
  • Hela cell lysate.
• 特記事項

  Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

  Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファー
  PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• 精製度
  Tissue culture supernatant
• ポリ/モノ
  モノクローナル
• クローン名
  EP1838Y
• アイソタイプ
  IgG
• 研究分野
  • Signal Transduction
  • Protein Phosphorylation
  • Tyrosine Phosphatases

  • Cardiovascular
  • Atherosclerosis
  • Diabetes associated

関連製品

• Positive Controls
  • HeLa nuclear extract lysate (ab14655)

アプリケーション

ターゲット情報

• 機能
  May play an important role in CKII- and p60c-src-induced signal transduction cascades.
• 配列類似性
  Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.
  Contains 1 tyrosine-protein phosphatase domain.
• 翻訳後修飾
  Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a 4-amino-3-isothiazolidinone serine cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction.
• 細胞内局在
  Endoplasmic reticulum membrane.

• Target information above from: UniProt accession P18031 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 5770 Human
  • Omim: 176885 Human
  • SwissProt: P18031 Human
  • Unigene: 417549 Human
• 別名
  • PTP1B antibody
  • Non receptor tyrosine phosphatase 1 antibody
  • Protein phosphotyrosylphosphatase 1B antibody

  • Protein tyrosine phosphatase 1B antibody
  • Protein tyrosine phosphatase non receptor type 1 antibody
  • Protein tyrosine phosphatase placental antibody
  • Protein-tyrosine phosphatase 1B antibody
  • PTN1_HUMAN antibody
  • PTP 1B antibody
  • PTP-1B antibody
  • PTPN 1 antibody
  • PTPN1 antibody
  • Tyrosine protein phosphatase non receptor type 1 antibody
  • Tyrosine-protein phosphatase non-receptor type 1 antibody

  see all

プロトコール

• Western blot protocols