製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to PTOP
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rat, Horse, Guinea pig, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within C terminal amino acids 351-400 (PRTSAQELCS VWEPPERHRD TSAFQYKYET PSASLHTQVQ TARLSPQLVA) of Mouse PTOP (NP_001012656).

  • ポジティブ・コントロール
    • Mouse muscle tissue lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab104297 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 58 kDa. Mouse protein 45kD Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能
    Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis.
  • 細胞内局在
    Nucleus. Chromosome > telomere.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Acd antibody
    • ACD_HUMAN antibody
    • Adrenocortical dysplasia homolog antibody
    • Adrenocortical dysplasia protein homolog antibody
    • PIP1 antibody
    • POT1 and TIN2 organizing protein antibody
    • POT1 and TIN2-interacting protein antibody
    • TIN2 interacting protein 1 antibody
    • TINT1 antibody
    • TPP1 antibody
    see all

画像

  • Anti-PTOP antibody (ab104297) at 1 µg/ml + Mouse muscle tissue lysate at 10 µg

    Predicted band size : 58 kDa

プロトコール

参考文献

This product has been referenced in:

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