製品の概要

  • 製品名
    Anti-PTF1A antibody [1A2]
    PTF1A 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [1A2] to PTF1A
  • アプリケーション
    適用あり: IHC-P, WB, ELISA, Sandwich ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment (GST-tag) corresponding to Human PTF1A aa 250-328.
    Sequence:

    QAQKVIICHRGTRSPSPSDPDYGLPPLAGHSLSWTDEKQLKEQNIIRTAK VWTPEDPRKLNSKSSFNNIENEPPFEFVS


    Database link: Q7RTS3

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab57257 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 3 µg/ml.
WB Use a concentration of 1 - 5 µg/ml.
IF Use at an assay dependent concentration.
ELISA Use at an assay dependent concentration.
Sandwich ELISA Use at an assay dependent concentration.

ターゲット情報

  • 機能
    Transcriptional activator. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays an important role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells (By similarity). Plays an important role in cerebellar development.
  • 組織特異性
    Pancreas-specific (at protein level). Loss of expression is seen in ductal type pancreas cancers.
  • 関連疾患
    Defects in PTF1A are the cause of diabetes mellitus and cerebellar hypoplasia/agenesis (DMCH) [MIM:609069].
  • 配列類似性
    Contains 1 basic helix-loop-helix (bHLH) domain.
  • 細胞内局在
    Nucleus. Cytoplasm. In chronic pancreatitis associated with pancreas cancer preferentially accumulates in the cytoplasm of acinar/ductular complexes. In the cytoplasm loses its ability to form the PTF1 complex.
  • Information by UniProt
  • 参照データベース
  • 製品の状態
    PTF1A is a pancreas specific transcription factor. Mammalian studies have implicated important roles for the basic helix-loop-helix transcription factor PTF1A-p48 in the development of both exocrine and endocrine pancreas.
  • 別名
    • bHLH transcription factor p48 antibody
    • bHLHa29 antibody
    • Class A basic helix-loop-helix protein 29 antibody
    • Class II bHLH protein PTF1A antibody
    • Exocrine pancreas specific transcription factor p48 antibody
    • p48 DNA binding subunit of transcription factor PTF1 antibody
    • p48 DNA-binding subunit of transcription factor PTF1 antibody
    • PACA antibody
    • PAGEN2 antibody
    • Pancreas specific transcription factor 1a antibody
    • Pancreas transcription factor 1 subunit alpha antibody
    • Pancreas-specific transcription factor 1a antibody
    • PTF 1A antibody
    • PTF1 p48 antibody
    • PTF1-p48 antibody
    • Ptf1a antibody
    • PTF1A_HUMAN antibody
    • PTF1P48 antibody
    see all

Anti-PTF1A antibody [1A2] 画像

  • Western blot against tagged recombinant protein immunogen using ab57257 PTF1A antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa
  • PTF1A antibody (ab57257) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human esophagus.
  • Immunofluorescence of ab57257 on HeLa cell at the concentration of 10 ug/ml.

Anti-PTF1A antibody [1A2] (ab57257) 使用論文

ab57257 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your reply and for providing the order number.


Your credit note ID is *.


I am sorry that these antibodiesdid not perform as stated on the datasheets. If payment has already been made on the original order and y...

Read More

Thank you for your reply.

I would be happy to process a refund for you, since these antibodies are covered under our Abpromise, which is good for 6 months after purchase. To be able to process the refund, could you please provide me with the e...

Read More

Thank you for your reply.

What I meant by different targets against the same antibody, is that we sometimes have multiply antibodies that recognize the same target in our catalogue.

However, of the 3 antibodies you are using, the only...

Read More

Thank you for your reply and for providing the protocol information.

Based on what you have described, I think that the best way forward in this issue is send free of charge replacements for the antibodies in question. I could either replace ...

Read More

Thank you for contacting Abcam.

I am sorry that you are having some technical issues with a few of our antibodies. These antibodiesare covered under our Abpromise for six months andareguaranteed to work in IHC-P on human samples . If we canno...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録