製品の概要

  • 製品名Anti-PSMC3IP antibody
    PSMC3IP 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PSMC3IP
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Goat, Horse, Chicken, Cow, Cat, Dog, Pig, Zebrafish
  • 免疫原

    Synthetic peptide derived from within residues: PEEKEQVYRE RQKYCKEWRK RKRMATELSD AILEGYPKSK KQFFEEVGIE , corresponding to internal sequence amino acids 143-192 of Human PSMC3IP (NP_037422)

  • ポジティブ・コントロール
    • 721_B cell lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG

アプリケーション

Our Abpromise guarantee covers the use of ab82772 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 24 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

Titre using peptide based assay: 1/1562500.

ターゲット情報

  • 機能Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors.
  • 組織特異性Highly expressed in testis and colon.
  • 関連疾患Ovarian dysgenesis 3 (ODG3) [MIM:614324]: A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • 配列類似性Belongs to the HOP2 family.
  • 翻訳後修飾PTM: Phosphorylated by PKA, PKC and MAPK.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DBD interacting antibody
    • GT198 antibody
    • Homologous pairing protein 2 homolog antibody
    • Homologous-pairing protein 2 homolog antibody
    • HOP2 antibody
    • HOP2_HUMAN antibody
    • Nuclear receptor coactivator GT198 antibody
    • Proteasome 26S ATPase subunit 3 interacting protein antibody
    • Proteasome 26S ATPase subunit 3-interacting protein antibody
    • PSMC3 interacting protein antibody
    • PSMC3-interacting protein antibody
    • Psmc3ip antibody
    • Tat binding protein 1-interacting protein antibody
    • Tat-binding protein 1-interacting protein antibody
    • TBP-1-interacting protein antibody
    • TBP1 interacting protein antibody
    • TBPIP antibody
    see all

Anti-PSMC3IP antibody 画像

  • Anti-PSMC3IP antibody (ab82772) at 1 µg/ml + 721_B cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 24 kDa
    Observed band size : 24 kDa
    Additional bands at : 28 kDa,55 kDa. We are unsure as to the identity of these extra bands.

Anti-PSMC3IP antibody (ab82772) 使用論文

ab82772 has not yet been referenced specifically in any publications.

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