Mouse polyclonal to PRUNE
Full length human PRUNE protein (NP_067045.1).
- WB: Raw 264.7 cell lysate, NIH/3T3 cell lysate, and PRUNE transfected 293T cell lysate
ICC/IF: HeLa cell
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Constituents: 1X PBS, pH 7.2
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Protein A purified
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||Use a concentration of 1 µg/ml. Predicted molecular weight: 50 kDa.
||Use a concentration of 10 µg/ml.
Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.
Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas.
Belongs to the PPase class C family. Prune subfamily.
Cytoplasm. Nucleus. Cell junction > focal adhesion. In some transfected cells a nuclear staining is also observed.
Information by UniProt
- DRES-17 antibody
- DRES17 antibody
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