製品の概要

  • 製品名Anti-PROX1 antibody
    PROX1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PROX1
  • アプリケーション適用あり: ICC/IF, WB, IHC-Frmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Recombinant fragment corresponding to Human PROX1 (C terminal). (Homeo domain and Prospero domain)
    Database link: Q92786

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab101851 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF 1/750 - 1/1000.
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 82 kDa.
IHC-Fr Use at an assay dependent concentration.

ターゲット情報

  • 機能Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
  • 組織特異性Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
  • 配列類似性Belongs to the Prospero homeobox family.
    Contains 1 Prospero-type homeobox DNA-binding domain.
  • ドメインThe prospero-type homeobox DNA-binding domain is essential for repression of RORG transcriptional activator activity.
  • 細胞内局在Nucleus. RORG promotes its nuclear localization.
  • Information by UniProt
  • 参照データベース
  • 製品の状態Prox1 is a specific and required regulator of the development of the lymphatic system and that the vascular and lymphatic systems develop independently. Sox18 directly activates Prox1 transcription by binding to its proximal promoter.
  • 別名
    • Homeobox prospero like protein antibody
    • Homeobox prospero like protein PROX1 antibody
    • Homeobox prospero-like protein PROX1 antibody
    • Prospero homeobox 1 antibody
    • Prospero homeobox protein 1 antibody
    • Prospero related homeobox 1 antibody
    • prospero-related homeobox gene 1 antibody
    • PROX 1 antibody
    • PROX-1 antibody
    • PROX1 antibody
    • PROX1_HUMAN antibody
    • zgc:111888 antibody
    see all

Anti-PROX1 antibody 画像

  • Immunohistochemistry (Frozen sections) analysis of mouse embryo (day 13.5) tissue sections labelling PROX1 (red) with ab101851. Green - CD31, lv - large vessel, arrows - blood vessels, sg - sympathetic ganglion.

Anti-PROX1 antibody (ab101851) 使用論文

ab101851 has not yet been referenced specifically in any publications.

Product Wall

Application Immunocytochemistry/ Immunofluorescence
Sample Human Cell (h9 cell line upon differentiation)
Specification h9 cell line upon differentiation
Blocking step Serum as blocking agent for 10 minute(s) · Concentration: 5% · Temperature: 25°C
Fixative Paraformaldehyde
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投稿 Oct 22 2014

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"