製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to Protor-1
  • 特異性
    ab113269 is predicted to not cross-react with other Protor protein family members.
  • アプリケーション
    適用あり: ICC, ICC/IF, WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    A 20 amino acid synthetic peptide corresponding to the C terminal region of Human Protor-1 (NP_851850).

  • ポジティブ・コントロール
    • SK N SH cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab113269 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC Use a concentration of 5 µg/ml.
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 43 kDa.
IHC-P Use at an assay dependent concentration.

ターゲット情報

  • 機能
    Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.
  • 組織特異性
    Most abundant in kidney and liver. Also highly expressed in brain, spleen, testis and placenta. Overexpressed in several colorectal tumors.
  • 配列類似性
    Belongs to the PROTOR family.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Arhgap8 antibody
    • AU043908 antibody
    • C030017C09Rik antibody
    • C78947 antibody
    • FLJ20185 antibody
    • FLJ20185k antibody
    • MGC109513 antibody
    • MGC32512 antibody
    • PP610 antibody
    • Proline rich 5 (renal) antibody
    • Proline-rich protein 5 antibody
    • Protein observed with Rictor-1 antibody
    • Protor-1 antibody
    • PROTOR1 antibody
    • PRR5 antibody
    • PRR5_HUMAN antibody
    • PTOR1 antibody
    • Rho GTPase activating protein 8 antibody
    • RP1-181C9.3 antibody
    see all

画像

  • Immunofluorescence of Protor-1 in mouse brain tissue with ab113269 at 20 ug/mL.
  • All lanes : Anti-Protor-1 antibody (ab113269) at 1 µg/ml

    Lane 1 : SK N SH cell lysate
    Lane 2 : SK N SH cell lysate with blocking peptide

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 43 kDa
  • Immunohistochemistry of Proctor-1 in mouse brain tissue with ab113269 at 5 ug/mL.

参考文献

This product has been referenced in:
  • Castellanos-Martín A  et al. Unraveling heterogeneous susceptibility and the evolution of breast cancer using a systems biology approach. Genome Biol 16:40 (2015). Read more (PubMed: 25853295) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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