製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to Protein S
  • アプリケーション
    適用あり: RIA, WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Protein S purified from Human plasma.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab110812 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
RIA Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 75 kDa.
ELISA Use at an assay dependent dilution.

ターゲット情報

  • 機能
    Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
  • 組織特異性
    Plasma.
  • 関連疾患
    Defects in PROS1 are the cause of protein S deficiency (PROS1D) [MIM:612336]; also known as thrombophilia due to protein S deficiency. PROS1D is a cause of hereditary thrombophilia, a hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Based on the plasma levels of total and free PROS1 antigen as well as the serine protease-activated protein C cofactor activity, three types of PROS1D have been described: type I, characterized by reduced total and free PROS1 antigen levels together with reduced anticoagulant activity; type III, in which only free PROS1 antigen and PROS1 activity levels are reduced; and the rare type II which is characterized by normal concentrations of both total and free PROS1 antigen, but low cofactor activity.
  • 配列類似性
    Contains 4 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 2 laminin G-like domains.
  • 翻訳後修飾
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • 細胞内局在
    Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Preproprotein S antibody
    • Propiece of latent protein S antibody
    • PROS 1 antibody
    • PROS antibody
    • PROS_HUMAN antibody
    • proS1 antibody
    • Protein S alpha antibody
    • Protein Sa antibody
    • PS 21 antibody
    • PS 22 antibody
    • PS 23 antibody
    • PS 24 antibody
    • PS 25 antibody
    • PS 26 antibody
    • PS21 antibody
    • PS22 antibody
    • PS23 antibody
    • PS24 antibody
    • PS25 antibody
    • PS26 antibody
    • PSA antibody
    • THPH5 antibody
    • THPH6 antibody
    • Vitamin K dependent protein S antibody
    • Vitamin K-dependent plasma protein S antibody
    • Vitamin K-dependent protein S antibody
    see all

プロトコール

Anti-Protein S antibody (ab110812) 使用論文

ab110812 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab110812.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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